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Synthesis of [ 14 C]WIN 54954
Author(s) -
Ellames George J.,
Kunec Ellen K.
Publication year - 1991
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580290106
Subject(s) - chemistry , yield (engineering) , phenol , chemical synthesis , radiochemistry , organic chemistry , in vitro , biochemistry , physics , thermodynamics
A synthetic procedure for producing 5‐[5‐[2,6‐dichloro‐4‐(4,5‐dihydro‐2‐oxazolyl)‐( U ‐ 14 C)‐phenoxy]pentyl]‐3‐methylisoxazole, [ 14 C]WIN 54954 is described. The synthesis is achieved in seven steps with an overall radiochemical yield of 13.7%, using [ U ‐ 14 C]phenol as a source of radiolabel.