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Facile [ 14 C]methane preparation using the reduction of [ 14 C]methyl iodide by sodium borohydride
Author(s) -
Elbert Thomas,
Matucha Miroslav
Publication year - 1990
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580281214
Subject(s) - chemistry , sodium borohydride , methyl iodide , diborane , methane , yield (engineering) , inorganic chemistry , sodium iodide , iodide , borohydride , nuclear chemistry , organic chemistry , catalysis , boron , materials science , metallurgy
[ 14 C]Methane (440 mCi) was prepared using the reduction of [ 14 C]methyl iodide by sodium borohydride in diglyme in quantitative yield. The diborane formed was trapped as nonvolatile 9‐BBN. [ 14 C]Methane free of any accompanying gases was conveniently distributed into calibrated glass ampules by the aid of capillary vacuum manifold and freezing out by liquid nitrogen.