Premium
Synthese radioactive de sels d'ammonium quaternaires d'hydroxy imino methyl‐2 OU ‐4 pyridinyle par l'intermediaire de la N‐methyl formanilide‐ 14 C. II. Marquage par 14 C de l'iodure d'[hydroxyimino methyl‐2 methyl‐1 pyridinyle ou 2‐PAM Iodure et du diodure de trimethylène dioxy‐3,3′ bis [hydroxy imino methyl‐2 methyl‐1, pyridinyle] ou R‐665
Author(s) -
Madelmont J. C.,
Nicolas C.,
Maurizis J. C.,
Dupuy J. M.,
Garrigue H.,
Meyniel J. M.,
Demerseman P.,
SentenacRoumanou H.,
Veyre Et A.
Publication year - 1990
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580281205
Subject(s) - chemistry , pyridinium , medicinal chemistry , hydroxylamine , alkylation , pyridine , ammonium , stereochemistry , organic chemistry , catalysis
The two compounds were labelled by 14 C on the hydroxyimino methyl group substituted on the 2 positions of the pyridinium ring. The convenient pyridinium lithiated intermediates were formylated with N‐methyl 14 C‐formanilide. The hydroxyimino methyl groups were synthezised by reaction of the 14 C‐formyl compound with hydroxylamine. For the two species alkylation of pyridine was performed with methyliodide. Radiochemical yields were 50% and 20%.