Premium
Synthese radioactive de sels d'ammonium quaternaires d'hydroxy imino methyl‐2 OU‐4 pyridinium au moyen de la N‐methyl formanilide‐ 14 C. I ‐ marquage du dichlorure d'(hydroxyimino méthyl ( 14 c)‐2 pyridinyle)‐1 (aminocarbonyl‐4′ pyridinyle)‐1′ dimethyl éther ou hi‐6‐( 14 c); du dibromure de bis [hydroxyimino méthyl ( 14 c)‐4 pyridinyle]‐1,3 propane ou tmb‐4‐( 14 c) et du dibromure d'(hydroxyimino méthyl ( 14 c)‐4 pyridinyle)‐1 (méthyl‐3′ imidazolyle)‐3 propane ou pyrimidoxime‐( 14 C)
Author(s) -
Nicolas C.,
Madelmont J. C.,
Maurizis J. C.,
Garrigue H.,
Meyniel J. M.,
Demerseman P.,
SentenacRoumanou H.,
Veyre A.
Publication year - 1990
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580281204
Subject(s) - chemistry , pyridinium , formic acid , alkylation , formylation , medicinal chemistry , ammonium , hydroxylamine , pyridine , nuclear chemistry , organic chemistry , catalysis
The 14 C labelling of three compounds : HI‐6, TMB‐4 and pyrimidoxime is described from 14 C‐formic acid, sodium salt. The compounds were prepared by lithiation and formylation with N‐methyl ( 14 C)‐formanilide followed by introduction of the hydroxylamine moieties and alkylation of the pyridine. Radiochemical yields were, respectively, 24,5%, 30% and 30%.