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High‐yield nitration of benzene in the synthesis of 15 N‐labelled nitrobenzene, acetanilide, and diphenylamine
Author(s) -
Konior Raymond J.,
Yang Ling,
Walter Robert I.
Publication year - 1990
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580281103
Subject(s) - acetanilide , chemistry , diphenylamine , nitration , nitrobenzene , benzene , yield (engineering) , medicinal chemistry , aniline , nuclear chemistry , organic chemistry , catalysis , materials science , metallurgy
Labelled H 15 NO 3 was used as the least‐cost source of nitrogen label to prepare nitrobenzene by reaction of acetyl nitrate with excess benzene. This labelled product was subsequently converted to acetanilide‐ 15 N and diphenylamine‐ 15 N.