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Myocardial imaging agents: Synthesis, characterization and evaluation of [(Z) and (Z,E)‐(1‐[ 82 br]bromo‐1‐penten‐5‐yl)]triphenylphosphonium cations
Author(s) -
Srivastava P. C.,
Knapp F. F.,
Callahan A. P.,
Goldstein B. M.
Publication year - 1990
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580281008
Subject(s) - bromine , chemistry , phosphonium , yield (engineering) , myocardial imaging , crystal structure , radiochemistry , medicinal chemistry , nuclear chemistry , crystallography , organic chemistry , nuclear medicine , medicine , materials science , metallurgy
The phosphonium compounds, [(Z) and (Z/E)‐(1‐bromo‐1‐penten‐5‐yl)]triphenylphosphonium iodides (yield, 65–70%) and the corresponding bromine‐82‐labeled analogues have been prepared as potential myocardial imaging agents. The 2/1 isomer composition of the Z/E mixture has been confirmed by single crystal X‐ray analysis. The radiobrominated (Z)‐isomer and (Z/E)‐mixture both show high heart uptake and high heart/blood ratios in rats. These data suggest that the bromine‐75 and bromine‐76‐labeled agents could be good candidates for myocardial imaging using positron emission computed tomography.