Premium
Stereoselective semi‐hydrogenation and deuteration of a diacetylenic precursor of leukotriene B 4 methyl ester
Author(s) -
Pontikis Renée,
Merrer Yves Le,
Depezay JeanClaude,
Pétillot Yves,
Rousseau Bernard,
Beaucourt Jean Pierre
Publication year - 1990
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580281004
Subject(s) - chemistry , deuterium , stereoselectivity , catalytic hydrogenation , organic chemistry , catalysis , leukotriene c4 , leukotriene , leukotriene b4 , medicinal chemistry , medicine , physics , quantum mechanics , inflammation , asthma
[6,7,14,15‐ 2 H 4 )‐Leukotriene B 4 methyl ester was prepared by reduction with deuterium gas of a suitable precursor (deuterium incorporation ≥ 90%). Several catalytic semi‐hydrogenations were effected in order to determine the best conditions for the labeling step.