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Synthesis of L‐6‐[ 123 I]iodo‐ m ‐tyrosine a potential spect brain imaging agent
Author(s) -
Adam Michael J.,
Ponce Yolanda Zea,
Berry Joffre M.
Publication year - 1990
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580280911
Subject(s) - chemistry , chloramine t , halogenation , tyrosine , radiochemistry , yield (engineering) , high performance liquid chromatography , biodistribution , chromatography , organic chemistry , biochemistry , materials science , metallurgy , in vitro
L‐6‐[ 123 I]Iodo‐ m ‐tyrosine was synthesized by the direct iodination of L‐ m ‐tyrosine with [ 123 I]‐NaI and Chloramine‐T. The product was purified by reverse phase HPLC to give the final product in 57% radiochemical yield with a radiochemical purity of greater than 97%.