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Synthesis of sodium 3‐ethyl‐7‐isopropyl‐[2‐ 14 C]‐azulene‐1‐sulfonate
Author(s) -
Suzaka Hiroaki,
Tomiyama Tsuyoshi,
Ikegami Shiro
Publication year - 1990
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580280804
Subject(s) - chemistry , sulfonate , isopropyl , yield (engineering) , sodium , azulene , sodium cyanide , potassium , potassium cyanide , nuclear chemistry , cyanide , medicinal chemistry , organic chemistry , materials science , metallurgy
Sodium 3‐ethyl‐7‐isopropylazulene‐1‐sulfonate 1 , which has been found to be a potent and chemically stable agent having anti‐inflammatory and anti‐ulcerous activity, was synthesized in 14 C‐labelled form by using potassium [ 14 C]‐cyanide. 14 C‐Labelled 1 with a specific activity of 9.02 mCi/mmol was prepared in eight steps in 21.9% overall chemical yield from 3‐( t ‐butyldiphenylsilyloxy)propyl tosylate 10 .
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