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A rapid and efficient synthesis of 2‐deoxy‐2‐[ 18 F]fluoroacetamido‐D‐mannopyranose and ‐D‐galactopyranose
Author(s) -
Tada Masao,
Oikawa Atsushi,
Iwata Ren,
Sato Kazunori,
Kubota Kazuo,
Fujiwara Takehiko,
Sugiyama Hiroshi,
Abe Yoshinao,
Sato Tachio,
Matsuzawa Taiju,
Takahashi Hiromu,
Wakui Akira,
Ido Tatsuo
Publication year - 1990
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580280715
Subject(s) - chemistry , yield (engineering) , fluoride , radiochemistry , ethyl bromoacetate , nuclear chemistry , cyclotron , medicinal chemistry , stereochemistry , organic chemistry , inorganic chemistry , ion , materials science , metallurgy
Rapid and efficient syntheses of 2‐deoxy‐2‐[ 18 F]fluoroacetamido‐D‐mannopyranose ( 1 ) and ‐D‐galactopyranose ( 2 ), respectively, starting from [ 18 F]fluoride and ethyl bromoacetate are described. [ 18 F]Fluoride was produced by the 18 O (p, n) 18 F nuclear reaction using the cyclotron. The total times required for synthesis of ( 1 ) and ( 2 ) are ca . 80 min. The radiochemical yield and purity of ( 1 ) are an 18% and ≥98%, respectively. Compound ( 2 ) is also synthesized with the same radiochemical yield and purity.