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Synthesis of tritium labelled 1‐(3,4‐dichlorophenyl)‐3‐(methylamino)propanol hydrochloride
Author(s) -
Hill John A.,
Wisowaty James C.
Publication year - 1990
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580280710
Subject(s) - chemistry , hydrochloride , tritium , propanol , specific activity , radiochemistry , nuclear chemistry , medicinal chemistry , organic chemistry , enzyme , physics , methanol , nuclear physics
1‐(3,4‐Dichlorophenyl)‐3‐(methylamino)propanol hydrochloride, 1 , a potential antidepressant, was synthesized by a two‐step method in the [ 3 H]‐labelled form with specific activity 12.5 mCi/mmol suitable for drug metabolism and disposition studies (1).