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Enantiospecific synthesis of [1‐ 3 H]‐(+)‐pseudoephedrine hydrochloride
Author(s) -
Hill John A.,
Scharver Jeffrey D.
Publication year - 1990
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580280608
Subject(s) - pseudoephedrine , chemistry , hydrochloride , enantiomer , stereochemistry , organic chemistry , ephedrine , pharmacology , medicine
The naturally occurring dextrorotary enantiomer (+)‐pseudoephedrine, 1 , was synthesized (1) in the [ 3 H]‐labelled form with specific activity 17.5 Ci/mmol suitable for development of a radioimmunoassay procedure. The chirally specific route from L ‐alanine to [1‐ 3 H]‐ d ‐pseudoephedrine hydrochloride was based on the use of α‐amino acids as chiral educts for asymmetric products as developed by Rapoport.