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Synthesis and radioiodination of ten aryl‐carbohydrate compounds for labeling monoclonal antibodies
Author(s) -
Warren S. D.,
Ali S. A.,
Richter K. Y.,
Krohn K. A.
Publication year - 1990
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580280502
Subject(s) - chemistry , reductive amination , monoclonal antibody , aryl , amination , carbohydrate , halogenation , labelling , antibody , combinatorial chemistry , biochemistry , organic chemistry , catalysis , alkyl , immunology , biology
Abstract Ten aryl‐carbohydrate ligands have been synthesized that potentially increase the tumor retention and decrease the deiodination of iodinated monoclonal antibodies used in the imaging and treatment of cancer. The compounds were synthesized via reductive amination reactions, purified with cation exchange chromatography, and characterized using 1 H and 13 C NMR. These compounds were then radioiodinated to assess their iodination characteristics, for subsequent experiments involving attachment to monoclonal antibodies.