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Synthesis of stable isotope‐labelled analogs of the cysteine and N‐acetylcysteine conjugates of tetrachloroethylene
Author(s) -
Bartels Michael J.,
Miner Virginia W.
Publication year - 1990
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580280212
Subject(s) - chemistry , tetrachloroethylene , cysteine , conjugate , acetylcysteine , deuterium , organic chemistry , stereochemistry , trichloroethylene , enzyme , antioxidant , mathematical analysis , mathematics , physics , quantum mechanics
Stable isotope‐labelled analogs of the cysteine and N‐acetylcysteine conjugates of tetrachloroethylene have been prepared. S‐(1,2,2‐Trichlorovinyl)‐DL‐cysteine‐3,3‐ 2 H 2 was synthesized in a rapid, one‐step procedure from tetrachloroethylene and DL‐cysteine‐3,3‐ 2 H 2 . Unlabelled S‐(1,2,2‐trichlorovinyl)‐L‐cysteine was prepared in a similar fashion. The corresponding 13 C‐N‐acetyl‐S‐(1,2,2‐trichlorovinyl)cysteine compounds were then prepared via acetylation of the deuterated and unlabelled cysteine conjugates with 13 C‐acetyl chloride.