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Synthesis of 2‐[4‐(diphenylmethyl)‐1‐piperazinyl]ethyl methyl (±)‐1,4‐dihydro‐2,6‐dimethyl‐4‐(m‐nitrophenyl)‐3,5‐[6‐ 14 C]pyridinedicarboxylate dihydrochloride ([ 14 C]CV‐4093 (2HCl))
Author(s) -
Tada Norio,
Kajino Masahiro,
Watanabe Masazumi,
Hayashi Nobuyoshi
Publication year - 1989
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580271115
Subject(s) - chemistry , yield (engineering) , ethyl acetoacetate , carbon 14 , medicinal chemistry , nuclear chemistry , stereochemistry , organic chemistry , catalysis , materials science , metallurgy , physics , quantum mechanics
The carbon‐14 labelled compound (5) of 2‐[4‐(diphenylmethyl)‐1‐piperazinyl]ethyl methyl (±)‐1,4‐dihydro‐2,6‐dimethyl‐4‐(m‐nitrophenyl)‐3,5‐pyridinedicarboxylate dihydrochloride (CV‐4093 (2HCl)) was synthesized for the study of its metabolism and distribution in test animals. Starting from the commercially available ethyl[3‐ 14 C]acetoacetate (1), 5 was prepared by a modified Hantzsch synthesis, in an overall radiochemical yield of 23.7%.