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Carbon‐14 labelling of terbinafine, an antimycotic agent
Author(s) -
Andres Hendrik
Publication year - 1989
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580271110
Subject(s) - terbinafine , chemistry , moiety , alkyne , labelling , pharmacology , organic chemistry , antifungal , microbiology and biotechnology , biochemistry , catalysis , medicine , itraconazole , biology
Terbinafine is a new antimycotic agent which is currently being tested worldwide in clinical trials. The synthesis of [ 14 C]Terbinafine, labelled in the naphthalene methane moiety as well as in the tertiary butyl group are described. The key step of the latter is the aluminium‐mediated tertiary butylation of an alkyne.