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Synthesis of 1‐[ 11 C]‐D,L‐homocysteine thiolactone: A potential tracer for myocardial ischemia using PET
Author(s) -
Hamacher Kurt,
Hanuš Jan
Publication year - 1989
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580271106
Subject(s) - chemistry , thiolactone , yield (engineering) , high performance liquid chromatography , tracer , chemical synthesis , labelling , radiosynthesis , homocysteine , radiochemistry , chromatography , stereochemistry , positron emission tomography , nuclear medicine , biochemistry , in vitro , medicine , materials science , physics , nuclear physics , metallurgy
The synthesis of 1‐[ 11 C]‐D,L‐homocysteine thiolactone, a potential tracer for PET imaging of ischemic heart regions, is described. The labelling is achieved by reaction of [ 11 C]carbon dioxide with α‐lithiated S‐(tetrahydropyran‐2‐yl)3‐thiopropylisonitrile. Deprotection of the mercapto group and lactonisation of the resulting thioamino acid is accomplished in an acid catalysed reaction. The radiochemical yield obtained is 10 to 15% and the synthesis time, including the HPLC purification is about 45 min.