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The effect of catalytic reaction conditions on the incorporation of tritium in unsaturated compounds
Author(s) -
Shevchenko V. P.,
Yu. Nagayev I.,
Myasoedov N. F.
Publication year - 1989
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580271010
Subject(s) - chemistry , ammonium chloride , tritium , catalysis , labelling , double bond , chloride , organic chemistry , ammonium , medicinal chemistry , radiochemistry , biochemistry , physics , nuclear physics
We have obtained multiple‐tritium‐labelled 5‐α‐androstan‐3‐one, dihydropicrotoxin, dimethyl‐propyl‐3‐chloro‐butyl‐ammonium chloride, 2,2‐di(trifluoromethyl)‐3,3‐dicyanobicyclohept[2,2,1]ane, dihydroalprenolol, undecanoic acid, dihydro‐m,m'‐di‐tert.‐butyl‐p‐coumaric acid and dihydrofusicoccin. By varying the conditions for the hydrogenation of terminal double bonds one can considerably increase the molar radioactivity of such compounds through isotopic exchange. We discuss some tentative explanations of the effect of the labelling reaction conditions upon the synthesis of compounds with desired properties.