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A freeze dried formulation for the preparation of 99m Tc‐[V]‐DMS complex
Author(s) -
Chiotellis E.,
Varvarigou A.,
Archimandritis S.,
Gyftaki E.
Publication year - 1989
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580271007
Subject(s) - chemistry , radiochemistry , freeze drying , chromatography , nuclear chemistry , impurity , organic chemistry
A freeze dried kit formulation for the preparation of 99m Tc‐[V]‐DMS complex was developed, requiring a single step labeling procedure. Methods of analysis were also developed permitting identification of radiochemical impurities which may be present in radiopharmaceutical solution. 99m Tc‐[V]‐DMS prepared by the kit method was evaluated in experimental animals and human volunteers. Data demonstrated that the complex formed after kit reconstitution shows tumor seeking properties. Thyroid medullary carcinoma in patients was successfully detected 2 hrs post administration.