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Preparation of 2 H‐ and 3 H‐labelled carvone
Author(s) -
Banthorpe Derek V.,
Brown Geoffrey D.
Publication year - 1989
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580270909
Subject(s) - carvone , chemistry , yield (engineering) , reagent , bovine serum albumin , decomposition , organic chemistry , chromatography , essential oil , limonene , materials science , metallurgy
(‐)‐Carvone labelled with 2 H or 3 H at C‐10 was prepared by two methods. The first, involving a reversible ene reaction yielded 10‐deuteriocarvone with some substitution at other reactive centres. An improvement to this route involved the decomposition of an organozinc reagent of 10‐chloro‐carvone which gave a better yield of product substituted only at C‐10. As a preliminary to a possible radioimmunoassay with the above material, four derivatives of carvone linked to bovine serum albumin were prepared.