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Catalytic tritiation of splenopentine and diacetylsplenopentine via the di‐iodo‐tyrosine derivatives
Author(s) -
Oehlke J.,
Mittag E.,
Klebsch H.J.,
Niedrich H.
Publication year - 1989
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580270904
Subject(s) - chemistry , labelling , catalysis , tritium , halogenation , substrate (aquarium) , tyrosine , solvent , amino acid , stereochemistry , organic chemistry , biochemistry , physics , oceanography , nuclear physics , geology
Tritium labelled splenopentine (Arg‐Lys‐Glu‐Val‐Tyr‐OH) and diacetylsplenopentine (Nα‐ac‐Arg‐Nα‐ac‐Arg‐Nε‐ac‐Lys‐Glu‐Val‐Tyr‐OH) were prepared by the catalytic dehalotritiation of the corresponding diiodopeptides obtained by ICl‐iodination. Under conditious which proved to be optimal in foregoing model deuterations, a specific radioactivity of about 90% of the theoretical one was achieved. The labelling result was influenced noticeably by a transfer of solvent hydrogen directly to the substrate analogously as found in the dehalodeuterations of simple amino acid derivatives.