Premium
Deuteraction of DL‐4‐hydroxyphenyllactic acid
Author(s) -
Ten Brink H. J.,
Jakobs C.
Publication year - 1989
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580270815
Subject(s) - chemistry , isotope dilution , deuterium , ring (chemistry) , quantitative analysis (chemistry) , hydrogen , chromatography , organic chemistry , radiochemistry , combinatorial chemistry , mass spectrometry , physics , quantum mechanics
The preparation of [D 2 ]‐labelled DL‐4‐hydroxyphenyllactic acid by acid catalyzed hydrogen exchange at the aromatic ring is reported. Spectrometric analysis of the product shows that the deuteration is regiospecific and quantitative, which makes the deuterated compound suitable as an internal standard in the stable isotope dilution analysis of its naturally occurring analog in biological samples.