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Preparation of sodium 2‐mercapto‐[ 14 C]ethanesulfonate
Author(s) -
Jarý J.,
Grossmann V.,
Doležal S.,
Labsk´ J.
Publication year - 1989
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580270813
Subject(s) - chemistry , sodium , nuclear chemistry , sulfonate , sodium hydroxide , salt (chemistry) , inorganic chemistry , neutralization , medicinal chemistry , organic chemistry , antibody , immunology , biology
Starting from [1‐ 14 C]ethanol 1,2‐dibrom‐[ 14 C]‐ethane was prepared by an usual method through [ 14 C]‐ethylene. Sodium sulfite was alkylated by 1,2‐dibrom–[ 14 C]ethane and the formed sodium 2‐brom‐[ 14 C]ethane sulfonate was transferred without isolation to a labelled 2‐[(aminoiminomethyl)thio]‐[ 14 C]ethanesulfonic acid. After purification by crystallization of the acid 2‐mercapto‐[ 14 C]ethanesulfonic acid was prepared through guanidinium salt. After the neutralization of 2‐mercapto‐[ 14 C]ethanesulfonic acid by sodium hydroxide the corresponding sodium salt with specific activity 0.083 μCi/mmol (0.31 MBq/mmol) was prepared.