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Investigation on solvent hydrogen transfer during the catalytic deuteration of N‐acetyl‐3,5‐di‐iodo‐L‐tyrosineamide
Author(s) -
Oehlke J.,
Niedrich H.,
Zöpfl H.J.,
Franke P.
Publication year - 1989
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580270802
Subject(s) - chemistry , catalysis , solvent , deuterium , amide , hydrogen , hydrogen–deuterium exchange , dilution , substrate (aquarium) , mass spectrometry , organic chemistry , medicinal chemistry , chromatography , physics , oceanography , quantum mechanics , thermodynamics , geology
During the catalytic dehalodeuteration of N‐acetyl‐3,5‐di‐iodo‐L‐tyrosine amide solvent hydrogen was incorporated instead of deuterium up to an order of 70%. The major part of the solvent hydrogen was shown to be introduced into the reaction product independently of the dilution of the reacting gas. This direct transfer depends on type of solvent and catalyst and on the catalyst‐to‐substrate ratio in the same manner as found from deuterations of 4‐halogenated phenylalanine derivatives and dehydroproline. The distribution of deuterium in the reaction products was determined by mass spectrometry.