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Peracetic acid as a superior oxidant for preparation of [ 123 I]IBZM: A potential dopamine D‐2 receptor imaging agent
Author(s) -
Kung MeiPing,
Kung Hank F.
Publication year - 1989
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580270612
Subject(s) - peracetic acid , chemistry , oxidizing agent , hydrogen peroxide , yield (engineering) , persulfate , chloramine t , nuclear chemistry , organic chemistry , catalysis , materials science , metallurgy
Various oxidizing agents: chloramine‐T, hydrogen peroxide, sodium persulfate, m‐chloroperoxybenzoic acid and peracetic acid were examined as the oxidant for preparing radioiodinated IBZM (( S )‐(–)‐3‐ iodo‐2‐hydroxy‐6‐methoxy‐ N ‐[(1‐ethyl‐2‐pyrrolidinyl)methyl]benzamide), which is a useful dopamine D‐2 receptor imaging agent. Of all the oxidizing agents tested, peracetic acid appears to be the best agent for no‐carrier added radioiodination. The advantages of using peracetic acid as the oxidant for the preparation of [ 125 I] or [ 123 I] IBZM include: high radiochemical yield, high radiochemical purity, and short reaction time at room temperature.