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Synthesis of tritium labelled 4‐fluoro‐1‐[1–(2‐thienyl)]cyclohexylpiperidine ([ 3 H]‐FTCP); a tool for autoradiographic study of the phencyclidine binding site
Author(s) -
Thurkauf Andrew,
De Costa Brian R.,
Kiesewetter Dale O.,
Jacobson Arthur E.,
Rice Kenner C.
Publication year - 1989
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580270607
Subject(s) - chemistry , phencyclidine , tritium , radiochemistry , combinatorial chemistry , stereochemistry , biochemistry , receptor , nuclear physics , nmda receptor , physics
4‐Fluoro‐1–[1–(2‐thienyl)‐3‐cyclohexenyl)] piperidine was efficiently synthesized in four steps starting from cyclohexane‐1, 4‐dione monoethylene ketal. Catalytic tritiation of this key intermediate in the final step afforded the title compound.