Premium
Synthesis of [pyrrolidine‐ 14 C]‐cotinine from 14 C‐nicotine
Author(s) -
Peeters R.,
Daenens P.
Publication year - 1989
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580270515
Subject(s) - cotinine , chemistry , nicotine , pyrrolidine , yield (engineering) , chromatography , organic chemistry , radiochemistry , medicine , materials science , metallurgy
The synthesis and purification of 14 C‐cotinine is reported. 14 C‐nicotine is converted into 14 C‐dibromocotinine. Debromination of the latter results in 14 C‐cotinine which is purified by high performance liquid chromatography. The total radioactive yield of the synthesis is 44.8%. Starting from 500 μCi 14 C‐nicotine, 224 μCi 14 C‐cotinine is obtained with a specific activity of 0,23 mCi/mmol.