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Synthesis of [2‐ 14 C]nimodipine
Author(s) -
Scherling D.
Publication year - 1989
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580270514
Subject(s) - chemistry , isopropyl , nimodipine , ethyl acetoacetate , ammonia , ethanol , medicinal chemistry , boiling , toluene , organic chemistry , nuclear chemistry , catalysis , calcium
[2‐ 14 C]Nimodipine ( 8 ) was synthesized from isopropyl [3‐ 14 C]acetoacetate ( 5 ), which was converted to isopropyl 3‐amino[3‐ 14 C]crotonate ( 6 ) by reaction with gaseous ammonia in toluene. The 14 C‐labelled drug 8 was prepared by the cyclising Michael addition of the 3‐aminocrotonate 6 onto 2‐methoxyethyl 2‐(3‐nitrobenzylidene)acetoacetate ( 7 ) in boiling ethanol.