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The synthesis of E‐β‐[2‐ 14 C] indol‐3‐ylacrylic acid
Author(s) -
Morrison H.,
Mohammad Taj,
Severns B.
Publication year - 1989
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580270509
Subject(s) - chemistry , malonic acid , indole test , ring (chemistry) , condensation , chemical synthesis , stereochemistry , medicinal chemistry , organic chemistry , biochemistry , in vitro , physics , thermodynamics
We report a two step synthesis of indoleacrylic acid with a 14 C‐label in the 2‐position of the indole ring. [2‐ 14 C] Indole was formylated at the 3‐position with phosphorous oxychloride and DMF. Subsequent condensation with malonic acid provided the title compound with specific activity and radiochemical purity of 112 μCi/mmol and 93% respectively.