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Stoichiometric complexes tin‐methylenediphosphonate: Composition, biodistribution and elements of structure
Author(s) -
Osinski P.,
Poupaert J.,
Gallez B.,
Adline J.,
Dumont P.
Publication year - 1989
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580270505
Subject(s) - chemistry , stoichiometry , tin , biodistribution , solvent , homogeneous , metal , solvent extraction , inorganic chemistry , nuclear chemistry , radiochemistry , chromatography , organic chemistry , biochemistry , in vitro , extraction (chemistry) , physics , thermodynamics
Stoichiometric methylenediphosphonate (MDP) complexes of tin were prepared and their composition was determined as Sn (II)‐(MDP) 2 and Sn (IV)‐MDP. Biodistribution studies in mice have shown differences in organ uptake related to the valence of the metal ion and the nature of the injection solvent. N.M.R. spectra and gel filtration experiments indicated a simple, homogeneous structure for the stannous complex and the heterogeneous nature (hexa‐ and tetra‐coordinated) as well as a high apparent molecular weight for stannic species.