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Synthesis of leukotrienes labelled with deuterium: [11,12,14,15‐ 2 H 4 ]‐LTA 4 ‐LTC 4 , ‐LTD 4 and ‐LTE 4
Author(s) -
Lellouche J. P.,
Aubert F.,
Noel J. P.,
Boullais C.,
Beaucourt J. P.
Publication year - 1989
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580270415
Subject(s) - chemistry , saponification , epoxide , nucleophile , medicinal chemistry , catalysis , deuterium , organic chemistry , stereochemistry , physics , quantum mechanics
Abstract Semi‐hydrogenation by D 2 gas on Lindlar catalyst of an acetylenic precursor led to [11,12,14,15‐ 2 H 4 ]‐LTA 4 methyl ester 1a. Nucleophilic opening of the epoxide ring by amino thioacids afforded after saponification the corresponding deuterated peptidoleukotrienes LTC 4 , LTD 4 and LTE 4 .