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Synthesis of 14 C‐radiolabelled tilmicosin
Author(s) -
Crouse Gary D.,
Terando Norman H.
Publication year - 1989
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580270414
Subject(s) - chemistry , radiosynthesis , tilmicosin , reductive amination , piperidine , carbon 14 , amination , radiochemistry , chemical synthesis , organic chemistry , biochemistry , in vitro , in vivo , microbiology and biotechnology , catalysis , biology , antibiotics , physics , quantum mechanics
Tilmicosin was radiolabelled with carbon‐14 on the 3,5‐dimethylpiperidinyl sidechain as a requirement for animal metabolism studies. A new radiosynthesis of 3,5‐dimethyl‐piperidine was developed for this purpose. Incorporation into the desmycosin nucleus was accomplished by a reductive amination reaction.