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Synthesis of 14 C‐labelled 2‐[4‐(p‐fluorobenzoyl)piperidin‐1‐yl]‐2′‐acetonaphthone hydrochloride (E‐2001‐ 14 C)
Author(s) -
Karibe Norio,
Nakamura Takaharu,
Mishima Mannen,
Sugimoto Hachiro
Publication year - 1989
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580270408
Subject(s) - chemistry , hydrochloride , organic chemistry
14 C‐labelled 2‐[4‐(p‐fluorobenzoyl)piperidin‐1‐yl]‐2′‐acetonaphthone hydrochloride (4), a glutamate release inhibitor for studying the pharmacokinetic profiles of E‐2001, was synthesized in two steps using 2‐bromo‐2′‐[carbonyl‐ 14 C]‐acetonaphthone (1) as the labelled starting material.