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Synthesis of L‐[ 35 S]homocysteine thiolactone hydrochloride
Author(s) -
Hamacher Kurt
Publication year - 1989
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580270312
Subject(s) - chemistry , thiolactone , radiosynthesis , yield (engineering) , hydrochloride , radiochemistry , demethylation , ammonia , nuclear chemistry , organic chemistry , biochemistry , in vivo , materials science , dna methylation , microbiology and biotechnology , gene expression , gene , metallurgy , biology
L‐[ 35 S]Homocysteine thiolactone has been synthesized by demethylation of L‐[ 35 S]Methionine with sodium in liquid ammonia and subsequent lactonisation in acid solution. The radiochemical yield of the carrier added synthesis was in the range of 45 to 50 % with a radiochemical purity higher than 96 %.