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Radiochemical synthesis of [ 18 F]‐fluorothienylcyclohexylpiperidine ([ 18 F]FTCP)
Author(s) -
Kiesewetter Dale O.,
Rice Kenner C.,
Matson Mariena V.,
Finn Ronald D.
Publication year - 1989
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580270306
Subject(s) - chemistry , yield (engineering) , radiochemistry , fluoride , high performance liquid chromatography , silica gel , chemical synthesis , mesylate , chromatography , nuclear chemistry , organic chemistry , inorganic chemistry , biochemistry , materials science , metallurgy , in vitro
The radiochemical synthesis and purification of [ 18 F] N‐(1‐(2‐thienyl)‐cyclohexyl)‐4‐fluoropiperidine [[ 18 F]FTCP] is reported. [ 18 F]FTCP is prepared by [ 18 F] fluoride displacement on a mesylate precursor. The crude products are treated with borane to aid in the removal of an elimination product. Purification of the radiopharmaceutical involves a short silica gel BOND ELUT column and subsequently reverse phase HPLC. The final product has high chemical and radiochemical purity with the radiochemical yield optimized at nearly 30 percent (corrected for decay).