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Preparation du (+)‐Cis‐isobutyl‐3 dimethyl‐2,2 cyclopropane carboxylate de benzyl‐5 furylmethyle‐3 tritie, derive du pyrethrinoide (+)‐cismethrine
Author(s) -
Thang Docao,
Nam Nguyenhoang,
Hoellinger H.
Publication year - 1989
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580270213
Subject(s) - chemistry , cyclopropane , carboxylate , catalysis , methanol , medicinal chemistry , tritium , nuclear chemistry , organic chemistry , catalytic hydrogenation , ring (chemistry) , physics , nuclear physics
The catalytic reduction of (+)‐cismethrin 1 , a synthetic pyrethroid, with tritium gas in various solvents and in presence of different catalysts was studied. The best result was obtained with 5% Pd‐ BaSO 4 catalyst in methanol giving rise to 3 H‐5‐benzyl‐3‐furylmethyl (+)‐cis‐3‐isobutyl‐2,2‐dimethylcylopropane carboxylate 2 with a specific activity of 98 Ci. mmol −1 (3626 GBq. mmol −1 ). The incorporation of tritium was verified by H‐NMR and MS analyses.