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A facile synthesis of δ‐aminolevulinic acid (ALA) regioselectively labeled with 13 C and direct observation of enzymatic transformation from ALA to porphobilinogen (PBG)
Author(s) -
Kurumaya Katsuyuki,
Okazaki Takeo,
Seido Nobuo,
Akasaka Yuzuru,
Kawajiri Yoshiki,
Kajiwara Masahiro,
Kondo Masao
Publication year - 1989
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580270212
Subject(s) - porphobilinogen , chemistry , acetic acid , glycine , transformation (genetics) , enzyme , stereochemistry , sodium acetate , semisynthesis , organic chemistry , amino acid , biochemistry , gene
δ‐Aminolevulinic acid (ALA), labeled with 13 C at position 1, 2, 3, 4, or 5, was synthesized from 13 C‐labeled glycine, Meldrum's acid, or bromoacetate. The latter compounds were prepared from 13 C‐sodium acetate or 13 C‐acetic acid.Enzymatic transformation from ALA to porphobilinogen (PBG) was directly observed by 13 C‐NMR.