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13 C‐Markierung der Seitenketten von Mitoxantrone
Author(s) -
Blanz Joachim,
Zeller KlausPeter
Publication year - 1989
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580270113
Subject(s) - chemistry , yield (engineering) , mitoxantrone , labelling , stereochemistry , ethanol , biochemistry , chemotherapy , medicine , materials science , metallurgy , surgery
5,8‐Bis‐{[1‐ 13 C]‐{[2‐[(2‐hydroxyethyl)amino]ethyl]amino}}‐1,4‐dihydroxy‐9,10‐anthracenedione dihydrochloride is synthesized in 28% yield from [ 13 C]‐sodium cyanide via a five step sequence. The described synthesis of the sidechain, 2‐[(2‐aminoethyl)amino]ethanol, allows the labelling of each position of the carbon skeleton by taking use of only one intermediate, which is easy to prepare in very good yield.