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A convenient, high‐yielding preparation of 1,1,1‐trideuterioethane
Author(s) -
Bailey Austin L.,
Bates Gordon S.
Publication year - 1988
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580251113
Subject(s) - chemistry , yield (engineering) , dilithium , methanol , chloride , nuclear chemistry , medicinal chemistry , organic chemistry , deprotonation , metallurgy , ion , materials science
Coupling of methyl‐ 2 H 3 benzenesulphonate with the higher‐order organocuprate dilithium methyl‐2‐thienylcyanocuprate results in a virtually quantitative yield of 1,1,1‐trideuterioethane uncontaminated by other ethane species. Methyl‐ 2 H 3 benzenesulphonate is prepared from perdeuterated methanol and benzenesulphonyl chloride in 65–70% yield.