Premium
The preparation of 18 O, 15 N, and 14 C enriched N‐methyl‐2‐(4‐nitrophenoxy)‐ethanamine hydrochlorides and N‐methyl‐N‐(2‐hydroxyethyl)‐4‐nitroanilines
Author(s) -
Yilmaz Ibrahim,
Shine Henry J.
Publication year - 1988
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580251014
Subject(s) - chemistry , aniline , medicinal chemistry , amine gas treating , nitro , hydrochloride , organic chemistry , alkyl
Abstract Preparations are described of the hydrochloride of partially enriched N‐methyl‐2‐(4‐nitrophen[ 18 O]oxy)ethanamine, N‐methyl‐2‐(4‐nitrophenoxy)‐ethan[ 15 N]amine, and N‐methyl‐2‐(4‐nitro[1‐ 14 C]phenoxy)ethanamine, designated herein as [ 18 O]‐ 2 , [ 15 N]‐ 2 , and [ 14 C]‐ 2 , respectively. By base‐catalyzed rearrangement these enriched ethanamine derivatives were converted, respectively, into N‐methyl‐N‐(2‐[ 18 O]hydroxyethyl)‐4‐nitroaniline, N‐methyl‐N‐(2‐hydroxyethyl)‐4‐nitro[ 15 N]aniline, and N‐methyl‐(2‐hydroxyethyl)‐4‐nitro[1‐ 14 C]aniline, designated as [ 18 O]‐ 3 , [ 15 N]‐ 3 , and [ 14 C]‐ 3 .