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Synthesis of captopril labeled with 2 H, 3 H, 14 C, or 35 S
Author(s) -
Egli Peter,
Migdalof Bruce H.
Publication year - 1988
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580251008
Subject(s) - chemistry , carbon 14 , captopril , carbon 13 , radiochemistry , stable isotope ratio , isotope , isotopes of carbon , chemical synthesis , carbon fibers , kinetic isotope effect , stereochemistry , medicinal chemistry , deuterium , organic chemistry , nuclear physics , biochemistry , medicine , physics , blood pressure , in vitro , materials science , composite number , total organic carbon , composite material , radiology
Three routes for the synthesis of labeled captopril are described. The preferred route can be selected with regard to the desired position of the label. The chemical and radio‐chemical stability of captopril is discussed. An isotope effect was found in the IR spectrum when the side chain carbonyl carbon was labeled with carbon‐14.