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Synthesis of 13 C‐ and 14 C‐Labeled methanesulfinic and methanesulfonic acids
Author(s) -
Feil V. J.,
Huwe J. K.,
Dulik D. M.,
Fenselaum C.
Publication year - 1988
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580250915
Subject(s) - methanesulfonic acid , methyllithium , chemistry , sulfone , sulfur , sulfonyl , organic chemistry , sulfur dioxide , alkyl
The enzyme catalyzed displacement of the methyl sulfonyl group from pentachlorophenyl methyl sulfone, the m ‐chloroperoxybenzoic acid oxidation of methyl mercaptan and the reaction of methyllithium with sulfur dioxide are methods described for the synthesis of isotopically labeled methanesulfinic acid. The first two methods can be carried out on a milligram scale and are suitable for high specific activity preparations while the latter method is suitable for preparations on a gram scale. Conditions are also given for the preparation of isotopically labeled methanesulfonic acid.