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Preparation of 18 F‐labelled N‐fluoropyridinium triflate
Author(s) -
Oberdorfer Franz,
Hofmann Evelyn,
MaierBorst Wolfgang
Publication year - 1988
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580250912
Subject(s) - trifluoromethanesulfonate , chemistry , iodometry , reagent , yield (engineering) , fluorine , titration , medicinal chemistry , nuclear chemistry , radiochemistry , inorganic chemistry , organic chemistry , catalysis , materials science , metallurgy
N‐Fluoropyridinium triflate was labelled with 18 F proceeding through N‐trimethylsilylpyridinium triflate and [ 18 F]F 2 diluted to 1% in Ne. A typical experiment afforded this new fluorine‐18 transfer reagent with up to 46% radiochemical yield. The specific activity of 18 F‐labelled N‐fluoropyridinium triflate was determined by iodometric titration to be in the range of 4·10 −8 mg/Bq (1.5 mg/mCi; 1.67·10 −4 Ci/μM).