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Synthesis of [ 3 H]‐desciclovir, prodrug of the antiviral acyclovir
Author(s) -
Moorman Allan R.,
Hill John A.
Publication year - 1988
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580250907
Subject(s) - chemistry , prodrug , purine metabolism , purine , combinatorial chemistry , chemical synthesis , stereochemistry , radiochemistry , organic chemistry , biochemistry , enzyme , in vitro
The title compound was prepared by direct radiochemical synthesis from 2‐acetylamino‐9‐[(2‐hydroxyethoxy)methyl]‐9 H ‐purine. The product had a specific activity of 21.5 Ci mmol −1 and a radiochemical purity of 99.2%. The general approach described may be applicable to other “acyclic” nucleosides.