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[ 3 H]‐labelling of hydroxyethyl groups – synthesis of s‐2‐hydroxy [2‐ 3 H] ethyl) glutathione and of [ 3 H]‐melphalan
Author(s) -
Verny M.,
Nicolas C.
Publication year - 1988
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580250905
Subject(s) - chemistry , labelling , specific activity , sodium borohydride , radiochemistry , tritium , melphalan , ethanol , glutathione , nuclear chemistry , organic chemistry , enzyme , biochemistry , medicine , surgery , catalysis , physics , nuclear physics , transplantation
The easy preparation of 2‐bromo [1‐ 3 H] ethanol allows the tritium labelling of molecules bearing S‐ or N‐ hydroxyethyl groups. Thus S‐(2‐hydroxy [2‐ 3 H] ethyl) glutathione and [ 3 M]‐Melphalan were synthesised with specific radioactivities of around 10 mCi/mmol (370 MBq/mmol). These values could be theoretically raised to 10 Ci/mmol (370 GBq/mmol), according to the specific activity of the labelling precursor, sodium [ 3 H] borohydride.