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The synthesis of betaxolol labelled with tritium at high specific activity
Author(s) -
Allen John,
Tizot André
Publication year - 1988
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580250902
Subject(s) - tritium , chemistry , betaxolol , tritium illumination , specific activity , stimulation , catalysis , radiochemistry , organic chemistry , medicine , enzyme , timolol , physics , intraocular pressure , nuclear physics , ophthalmology
The synthesis of betaxolol, a new β‐blocking agent, labelled with tritium in high specific activity (49 Ci/mmol) is described. The tritium was incorporated into the molecule via a catalytic reductive debromination of the 2,6‐dibromobetaxolol precursor in the presence of tritium gas. This labelled compound has been used in receptor binding studies and also in studying the release of betaxolol from rat atrial slices on electrical stimulation.