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An improved synthesis of Carbon‐14 labelled carboxylic acids from Carbon‐14 labelled amino acids
Author(s) -
Ramamurthy T. V.,
Ravi S.,
Viswanathan K. V.
Publication year - 1988
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580250802
Subject(s) - chemistry , yield (engineering) , amino acid , amine gas treating , organic chemistry , carbon fibers , aqueous solution , phenylalanine , alcohol , tryptophan , carboxylic acid , solvent , tyrosine , biochemistry , materials science , composite number , metallurgy , composite material
Various Carbon–14 labelled amino acids including the aromatic ones viz., tyrosine, phenylalanine and tryptophan are converted to the corresponding carboxylic acids in high yield (70–;90%) on a micromolar scale synthesis by reaction with hydroxyl‐amine‐o‐sulphonic acid and in a short reaction time. The improvement in yield has been achieved by using aqueous alcohol as solvent in lieu of water alone as the medium of reaction.