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2‐ 18 F‐phenylalanine and 3‐ 18 f‐tyrosine — synthesis and preliminary data of tracer kinetics
Author(s) -
Murakami M.,
Takahashi K.,
Kondo Y.,
Mizusawa S.,
Nakamichi H.,
Sasaki H.,
Hagami E.,
Iida H.,
Kanno I.,
Miura S.,
Uemura K.
Publication year - 1988
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580250711
Subject(s) - phenylalanine , chemistry , tyrosine , amino acid , yield (engineering) , kinetics , radiochemistry , tracer , stereochemistry , biochemistry , materials science , physics , quantum mechanics , nuclear physics , metallurgy
2‐ 18 F‐phenylalanine and 3‐ 18 F‐tyrosine were synthesized by direct electrophilic substitution of L‐phenylalanine and L‐tyrosine with 18 F‐acetylhypofluorite. Both compounds were obtained in 30 % radiochemical yield based on 18 F‐acetylhypo‐fluorite within 60 min after the end of irradiation. In ratbrain, 30 % of the radioactivity was fixed into acid‐insoluble macromolecules and most of the free radioactivity existed as amino acids at one hour after 2‐ 18 F‐phenylalanine injection. In the case of 3‐ 18 F‐tyrosine, significant amounts of radioactivity existed as organic acids. The catecholamine fraction had negligible radioactivity in both cases. These results indicate that 2‐ 18 F‐phenylalanine is suitable for compartmental analysis for tissue accumulation because of its simple metabolic behavior.