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Preparation of 11 C‐nitromethane and an example of its use as a radiolabeling precursor
Author(s) -
Schoeps KarlOlof,
Halidin Christer,
StoneElander Sharon,
Långström Bengt,
Greitz Torgny
Publication year - 1988
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580250708
Subject(s) - chemistry , nitromethane , sodium iodide , sodium nitrite , iodide , nuclear chemistry , boiling , distilled water , organic chemistry , radiochemistry , chromatography
No‐carrier‐added 11 C‐nitromethane has been prepared from 11 C‐methyl iodide in a one‐pot reaction by use of silver or sodium nitrite in different solvents. A conversion of up to 87% was obtained within 3 min. It could easily be distilled from high‐boiling solvents to another reaction vessel (140°C, 3 min). Its potential as a radiolabeling precursor in condensations with aldehydes was shown in the synthesis of 11 C‐β‐nitrostyrene (85% conversion after 3–5 min).