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Synthesis of [5‐ 3 H] hemimellitic acid
Author(s) -
Shimoni Michael,
Azran Jacques,
Buchman Ouri
Publication year - 1988
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580250614
Subject(s) - chemistry , tritium , labelling , halogenation , hydrogen , radiochemistry , nuclear chemistry , organic chemistry , biochemistry , physics , nuclear physics
1,2,3‐Benzenetricarboxylic acid (hemimellitic acid) tritiated in position 5 has been labelled at a specific activity of 16.2 Ci/mmol, starting from 3‐bromo naphthalic anhydride. Attempts at direct bromination of the acid followed by tritiodebromination, or of general labelling by hydrogen‐tritium exchange gave poor results.